Protein Engineering

We study cellular responses to their environment, focusing on membranes, cellular communities, and hybrid structural biology. Using electron cryotomography with DNA nanotechnology, we also employ fluorescence microscopy, mass spectrometry, NMR, and cryoEM

We use the techniques of protein chemistry, molecular genetics, biophysics and cell biology. Centered on membrane proteins, we investigate both their fundamental properties and their applications in biotechnology.

We study carbohydrate and protein functions using organic synthesis and protein engineering. We aim to design and modify therapeutic and biotechnological systems, uncover biological mechanisms, and develop new tools for synthetic and chemical biology.

We apply protein engineering to decipher functional and structural correlates of immune receptor signalling and identify new therapeutic approaches to modulate T cell function in autoimmune, infection and cancer settings.

We engineer the catalytic properties of plant enzymes as a mechanism to improve plant stress tolerance and/or productivity. Our current focus is on oxygen-sensing Plant Cysteine Oxidases, which we modify to enhance plant adaptation to hypoxia.

T cells initiate immune responses to clear infections and cancers. They integrate signals from various surface receptors using intracellular signalling molecules. We use quantitative methods to understand this process and enhance human health.

Our research centers around the influenza neuraminidase protein as a promising target for therapeutic interventions, including antibodies, drugs, and vaccines.

Creating biotechnologies at the interface of control engineering, synthetic biology and robotics.

Our research balances the investigation of fundamental science with the development of technologies and designer biomaterials to address some of the major healthcare challenges across diagnostics, advanced therapeutics and regenerative medicine.

We investigate protein-linked oligosaccharides through the development of techniques that span protein engineering, chemical biology and mass spectrometry. Our goal is to pin-point glycan structures responsible for discrete biological disease processes..

We investigate the signalling mechanisms that link oxygen availability to plant growth and development, to understand adaptations to oxygen fluctuations throughout evolution and to design novel biotechnological strategies.

We investigate the intimate relationship between ion channel structure and function. We focus on their molecular mechanisms at an atomic level and their role in physiology and disease.