Bio-nanotechnology

We investigate cellular communication by uncovering signaling roles of innate electrophiles and nucleotides. We pioneered photocaged electrophile tools to trigger and profile signaling, revealing genome-protective and drug-relevant pathways.

We study cellular responses to their environment, focusing on membranes, cellular communities, and hybrid structural biology. Using electron cryotomography with DNA nanotechnology, we also employ fluorescence microscopy, mass spectrometry, NMR, and cryoEM

We use the techniques of protein chemistry, molecular genetics, biophysics and cell biology. Centered on membrane proteins, we investigate both their fundamental properties and their applications in biotechnology.

We investigate the mechanisms of interaction between biological and synthetic materials to design and engineer new systems for treating diseases such as cancer, chronic infections and neurological disorders.

The biomedical ultrasonics, biotherapy and biopharmaceuticals laboratory (BUBBL) investigate mechanisms that simultaneously enhance non-invasive therapy and enable real-time monitoring and control of the therapeutic process deep within the body.

We focus on computational modelling of materials and structures with a major focus on the multiphysics of neurons and brain and applications in Ultrasound Neuromodulation and TBI. We develop and use state-of-the-art advanced numerical techniques.

We study carbohydrate and protein functions using organic synthesis and protein engineering. We aim to design and modify therapeutic and biotechnological systems, uncover biological mechanisms, and develop new tools for synthetic and chemical biology.

Research is focused on utilising the tools of synthetic biology to develop reprogrammable cells (SimCells), vehicles for drug delivery and generation of bioenergy.

Our group studies mechanisms and machines of gene expression using single-molecule biophysical methods and biochemistry. We observe single biomachines in real time, both "in vitro" and inside living cells.

We apply theoretical and computational tools from statistical mechanics to study how complex behaviour emerges from the interaction of many individual objects. We are particularly interested in biological physics and the dynamics of soft-matter.

T cells initiate immune responses to clear infections and cancers. They integrate signals from various surface receptors using intracellular signalling molecules. We use quantitative methods to understand this process and enhance human health.

Our research balances the investigation of fundamental science with the development of technologies and designer biomaterials to address some of the major healthcare challenges across diagnostics, advanced therapeutics and regenerative medicine.

We investigate the intimate relationship between ion channel structure and function. We focus on their molecular mechanisms at an atomic level and their role in physiology and disease.