Directed Evolution

The biomedical ultrasonics, biotherapy and biopharmaceuticals laboratory (BUBBL) investigate mechanisms that simultaneously enhance non-invasive therapy and enable real-time monitoring and control of the therapeutic process deep within the body.

We study carbohydrate and protein functions using organic synthesis and protein engineering. We aim to design and modify therapeutic and biotechnological systems, uncover biological mechanisms, and develop new tools for synthetic and chemical biology.

We apply protein engineering to decipher functional and structural correlates of immune receptor signalling and identify new therapeutic approaches to modulate T cell function in autoimmune, infection and cancer settings.

We use ecology and evolution to understand and engineer microbial communities, including the human microbiome.

We apply theoretical and computational tools from statistical mechanics to study how complex behaviour emerges from the interaction of many individual objects. We are particularly interested in biological physics and the dynamics of soft-matter.

We focused on understanding the fundamental evolutionary processes that drive the spread and maintenance of antibiotic resistance, primarily using controlled in vitro experimental evolution in the opportunistic pathogenic bacterium Pseudomonas aeruginosa.

Creating biotechnologies at the interface of control engineering, synthetic biology and robotics.