Biomedicine

We investigate cellular communication by uncovering signaling roles of innate electrophiles and nucleotides. We pioneered photocaged electrophile tools to trigger and profile signaling, revealing genome-protective and drug-relevant pathways.

We develop and apply mathematical and computational models to study cell and developmental biology at the cell and tissue levels. Combined with experiments, they provide insights into the mechanisms of embryo development.

We study cellular responses to their environment, focusing on membranes, cellular communities, and hybrid structural biology. Using electron cryotomography with DNA nanotechnology, we also employ fluorescence microscopy, mass spectrometry, NMR, and cryoEM

We aim to decipher how the adaptive immune system goes wrong in disease, and how this can be used in diagnostics and therapeutics using cutting-edge experimental and computational approaches.

We use the techniques of protein chemistry, molecular genetics, biophysics and cell biology. Centered on membrane proteins, we investigate both their fundamental properties and their applications in biotechnology.

We investigate the mechanisms of interaction between biological and synthetic materials to design and engineer new systems for treating diseases such as cancer, chronic infections and neurological disorders.

The biomedical ultrasonics, biotherapy and biopharmaceuticals laboratory (BUBBL) investigate mechanisms that simultaneously enhance non-invasive therapy and enable real-time monitoring and control of the therapeutic process deep within the body.

We study carbohydrate and protein functions using organic synthesis and protein engineering. We aim to design and modify therapeutic and biotechnological systems, uncover biological mechanisms, and develop new tools for synthetic and chemical biology.

We apply protein engineering to decipher functional and structural correlates of immune receptor signalling and identify new therapeutic approaches to modulate T cell function in autoimmune, infection and cancer settings.

We use ecology and evolution to understand and engineer microbial communities, including the human microbiome.

We use mathematical modelling and mechanics to explore morphogenesis, growth, diseases with a special emphasis on plants and the brain.

Research is focused on utilising the tools of synthetic biology to develop reprogrammable cells (SimCells), vehicles for drug delivery and generation of bioenergy.

Our group studies mechanisms and machines of gene expression using single-molecule biophysical methods and biochemistry. We observe single biomachines in real time, both "in vitro" and inside living cells.

We apply theoretical and computational tools from statistical mechanics to study how complex behaviour emerges from the interaction of many individual objects. We are particularly interested in biological physics and the dynamics of soft-matter.

We focused on understanding the fundamental evolutionary processes that drive the spread and maintenance of antibiotic resistance, primarily using controlled in vitro experimental evolution in the opportunistic pathogenic bacterium Pseudomonas aeruginosa.

T cells initiate immune responses to clear infections and cancers. They integrate signals from various surface receptors using intracellular signalling molecules. We use quantitative methods to understand this process and enhance human health.

Our research centers around the influenza neuraminidase protein as a promising target for therapeutic interventions, including antibodies, drugs, and vaccines.

Our research balances the investigation of fundamental science with the development of technologies and designer biomaterials to address some of the major healthcare challenges across diagnostics, advanced therapeutics and regenerative medicine.

We investigate protein-linked oligosaccharides through the development of techniques that span protein engineering, chemical biology and mass spectrometry. Our goal is to pin-point glycan structures responsible for discrete biological disease processes..

We focus on providing enabling technologies for regenerative medicine, including industrial scale cell/tissue culture in vitro, implantable biomaterials and processing, bio-manufacture of cellular therapeutics, and supply chain of living cells and tissues

We investigate how bacteria adapt to stress by examining DNA repair and mutagenesis. Using advanced microscopy and microfluidic devices, we visualize these processes in real-time, uncovering insights into variable phenotypes and mutation rates.

We investigate the mechanisms underlying biological processes by building biologically realistic mathematical/computational models, testing and refining them. We use currently available experimental data, and make experimentally verifiable predictions.

We use theoretical and computational methods to study the physics of soft matter and living systems. We are currently interested in collective behaviour of active systems and mechanobiology.